View source for 9kyl


==Crystal structure of human TRIP4 in complex with 11bp dsDNA==
<StructureSection load='9kyl' size='340' side='right'caption='[[9kyl]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9kyl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KYL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9kyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9kyl OCA], [https://pdbe.org/9kyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9kyl RCSB], [https://www.ebi.ac.uk/pdbsum/9kyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9kyl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRIP4_HUMAN TRIP4_HUMAN] Transcription coactivator of nuclear receptors which functions in conjunction with CBP-p300 and SRC-1 and may play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. Plays a role in androgen receptor transactivation and in testicular function (By similarity).<ref>PMID:12077347</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Guo WT]]
[[Category: Meng CY]]
[[Category: Wen Y]]
[[Category: Wu BX]]