View source for 9lb4


==mutant G490N/V492M of HEV-1 E2s domain==
<StructureSection load='9lb4' size='340' side='right'caption='[[9lb4]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9lb4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_E_virus_(strain_Burma) Hepatitis E virus (strain Burma)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9LB4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9LB4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.303&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BU3:(R,R)-2,3-BUTANEDIOL'>BU3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9lb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9lb4 OCA], [https://pdbe.org/9lb4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9lb4 RCSB], [https://www.ebi.ac.uk/pdbsum/9lb4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9lb4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAPSD_HEVBU CAPSD_HEVBU] Plays a role in the inhibition of host antibody-mediated neutralization without blocking viral cell entry.[UniProtKB:Q9YLQ9]  Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter. The capsid is composed of 60 copies linked to each other. Binds to the 5' end of the genomic RNA to mediate genome encapsidation (PubMed:14671114, PubMed:15557331). Binds to heparin surface proteoglycans (HSPGs) to mediate viral entry (By similarity). Additionally, the interactions with host ASGR1 and ASGR2 facilitate viral infection of hepatocytes (By similarity). Inhibits IFN production by blocking host TBK1-induced IRF3 phosphorylation (By similarity). The nuclear form probably modulates host gene expression (By similarity).[UniProtKB:P33426][UniProtKB:Q81871]<ref>PMID:14671114</ref> <ref>PMID:15557331</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Guiping W]]
[[Category: Hai Y]]
[[Category: Ningshao X]]
[[Category: Qing Z]]
[[Category: Shaowei L]]
[[Category: Zimin T]]
[[Category: Zizheng Z]]