View source for 9ldc


==The structure of TkoKptA/DNA/ADPR complex-B*==
<StructureSection load='9ldc' size='340' side='right'caption='[[9ldc]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ldc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermococcus_kodakarensis_KOD1 Thermococcus kodakarensis KOD1] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9LDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9LDC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EJT:(2~{S})-6-[(~{E})-[(2~{S},3~{S},4~{R})-5-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-2,3,4-tris(oxidanyl)pentylidene]amino]-2-azanyl-hexanoic+acid'>A1EJT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ldc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ldc OCA], [https://pdbe.org/9ldc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ldc RCSB], [https://www.ebi.ac.uk/pdbsum/9ldc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ldc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KPTA_THEKO KPTA_THEKO] Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Thermococcus kodakarensis KOD1]]
[[Category: Cao CL]]
[[Category: Gan JH]]
[[Category: Yang J]]
[[Category: Zhang WZ]]