View source for 9le2


==Consensus olfactory receptor bmOR6A2 in complex with mini-Golf trimeric protein==
<StructureSection load='9le2' size='340' side='right'caption='[[9le2]], [[Resolution|resolution]] 3.33&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9le2]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculoides Mus musculoides] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9LE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9LE2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.33&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EJH:(~{E})-dec-2-enal'>A1EJH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9le2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9le2 OCA], [https://pdbe.org/9le2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9le2 RCSB], [https://www.ebi.ac.uk/pdbsum/9le2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9le2 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Olfactory receptors (ORs) are a diverse superfamily of G protein-coupled receptors responsible for odor detection that are also implicated in non-olfactory physiological functions. OR6A2, a class II OR, selectively senses medium-chain aldehydes and belongs to a cluster of ORs genetically associated with the "soapy" perception of cilantro. It also modulates macrophage-mediated inflammatory responses. Structural studies of ORs have long been challenging. Using a back-mutation strategy, we engineered a functional OR6A2 variant (bmOR6A2) from a consensus OR6 (consOR6). Structures of bmOR6A2 in complex with aldehydes reveal a novel ligand-recognition mechanism involving a reversible Schiff base linkage with residue K(4.60), validated by mass spectrometry. By integrating structures of consOR6, molecular dynamics simulations, and functional assays, we identified a conserved D(45.51)Y(6.55)Y(7.41) triad critical for activation in class II ORs. These findings establish a practical strategy for decoding odorant recognition, offering new insights into olfaction signaling and applications in fragrance and therapeutic development.

Structural decoding of reversible covalent linkage of odorants in human olfactory receptor OR6A2.,Wang T, Wu Y, Wang L, Li S, Zhao F, Wu L, Liu Y, Qin J, Tan Q, Liu J, Zeng L, Chen Y, Gao S, Shui W, Zhao S, Hua T, Liu ZJ Cell. 2026 Jan 21:S0092-8674(25)01430-8. doi: 10.1016/j.cell.2025.12.017. PMID:41570822<ref>PMID:41570822</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 9le2" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculoides]]
[[Category: Synthetic construct]]
[[Category: Hua T]]
[[Category: Liu ZJ]]
[[Category: Wang T]]
[[Category: Wu LJ]]