View source for 9lfd


==Cryo-EM structure of human bradykinin receptor B2R bound to antagonist Win64338==
<StructureSection load='9lfd' size='340' side='right'caption='[[9lfd]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9lfd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9LFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9LFD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EJK:tributyl-[[4-[[(2~{S})-2-[[(~{E})-~{N},~{N}-dicyclohexylcarbamimidoyl]amino]-3-naphthalen-2-yl-propanoyl]amino]phenyl]methyl]phosphanium'>A1EJK</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9lfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9lfd OCA], [https://pdbe.org/9lfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9lfd RCSB], [https://www.ebi.ac.uk/pdbsum/9lfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9lfd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/OPRK_HUMAN OPRK_HUMAN] G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.<ref>PMID:12004055</ref> <ref>PMID:22437504</ref> <ref>PMID:7624359</ref> <ref>PMID:8060324</ref> [https://www.uniprot.org/uniprot/BKRB2_HUMAN BKRB2_HUMAN] Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.<ref>PMID:1314587</ref> <ref>PMID:1329734</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Xia M]]
[[Category: Zhang H]]