View source for 9lfl


==Cryo-EM structure of linker-extended biparatopic antibody BA1-GP4 in complex with TNFR2==
<StructureSection load='9lfl' size='340' side='right'caption='[[9lfl]], [[Resolution|resolution]] 3.73&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9lfl]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9LFL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9LFL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.73&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9lfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9lfl OCA], [https://pdbe.org/9lfl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9lfl RCSB], [https://www.ebi.ac.uk/pdbsum/9lfl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9lfl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TNR1B_HUMAN TNR1B_HUMAN] Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.<ref>PMID:14688072</ref> <ref>PMID:12370298</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Akiba H]]
[[Category: Fujita J]]
[[Category: Kamada H]]
[[Category: Kanada R]]
[[Category: Matsumoto S]]
[[Category: Miyata T]]
[[Category: Namba K]]
[[Category: Ohno H]]
[[Category: Okuno Y]]
[[Category: Otsuki T]]