View source for 9lgr


==Y-degron fused ZZ-domain of the Arabidopsis thaliana E3 ubiquitin-protein ligase BIG==
<StructureSection load='9lgr' size='340' side='right'caption='[[9lgr]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9lgr]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9LGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9LGR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9lgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9lgr OCA], [https://pdbe.org/9lgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9lgr RCSB], [https://www.ebi.ac.uk/pdbsum/9lgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9lgr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BIG_ARATH BIG_ARATH] Required for auxin efflux and polar auxin transport (PAT) influencing auxin-mediated developmental responses (e.g. cell elongation, apical dominance, lateral root production, inflorescence architecture, general growth and development). Controls the elongation of the pedicels and stem internodes through auxin action. Involved in the expression modulation of light-regulated genes. Represses CAB1 and CAB3 genes expression in etiolated seedlings. Confers sensitivity to the auxin transport inhibitors N-1-naphthylphthalamic acid (NPA), 2-carboxyphenyl-3-phenylpropane-l,2-dione (CPD), and methyl-2-chloro-9-hydroxyfluorene-9-carboxylate (CFM). Influences the polarized subcellular distribution of the auxin transporter PIN1 in response to auxin transport inhibitors. Plays a role in the regulation of responses to phytohormones such as auxin, cytokinins, ethylene and gibberellic acid (GA), particularly during light-mediated stimuli (e.g. shade ovoidance, etiolation). Required for pericycle cell activation to form lateral root primordia (LRP) in both high and low phosphate P conditions. Necessary for the plant-growth promotion and lateral root development mediated by the fungus Trichoderma virens.<ref>PMID:11485992</ref> <ref>PMID:12834402</ref> <ref>PMID:15634200</ref> <ref>PMID:15681664</ref> <ref>PMID:17652113</ref> <ref>PMID:19176721</ref> <ref>PMID:8314087</ref> <ref>PMID:9165751</ref> <ref>PMID:9390435</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Lee J]]
[[Category: Song HK]]
[[Category: Yang WS]]