View source for 9loc


==Cryo-EM structure of human FcRL5 bound to IgG-Fc==
<StructureSection load='9loc' size='340' side='right'caption='[[9loc]], [[Resolution|resolution]] 3.56&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9loc]] is a 13 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9LOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9LOC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.56&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9loc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9loc OCA], [https://pdbe.org/9loc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9loc RCSB], [https://www.ebi.ac.uk/pdbsum/9loc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9loc ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/FCRL5_HUMAN FCRL5_HUMAN] A chromosomal aberration involving FCRL5 has been found in cell lines with 1q21 abnormalities derived from Burkitt lymphoma. Duplication dup(1)(q21q32).<ref>PMID:11290337</ref> 
== Function ==
[https://www.uniprot.org/uniprot/FCRL5_HUMAN FCRL5_HUMAN] Plays an important role in B-cell response to antigen that acts both as a negative or positive coreceptor. Inhibits B-cell receptor (BCR) signaling in the absence of CR2 stimulation but engagement with CR2 and the BCR lead to a superior calcium response compared to CR2 and BCR costimulation (PubMed:30107486). May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. May play a role in fertilization (By similarity).[UniProtKB:Q68SN8]<ref>PMID:11453668</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chen SH]]
[[Category: Xiao JY]]