View source for 9lun


==Cryo-EM structure of Arabidopsis thaliana RGA in complex with GID1A, SLY1, and ASK2 (consensus map)==
<StructureSection load='9lun' size='340' side='right'caption='[[9lun]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9lun]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9LUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9LUN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GA3:GIBBERELLIN+A3'>GA3</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9lun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9lun OCA], [https://pdbe.org/9lun PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9lun RCSB], [https://www.ebi.ac.uk/pdbsum/9lun PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9lun ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RGA_ARATH RGA_ARATH] Probable transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway. Probably acts by participating in large multiprotein complexes that repress transcription of GA-inducible genes. Positively regulates XERICO expression in seeds. Upon GA application, it is degraded by the proteasome, allowing the GA signaling pathway. Compared to other DELLA proteins, it is the most sensitive to GA application. No effect of the BOI proteins on its stability. Its activity is probably regulated by other phytohormones such as auxin and ethylene, attenuation of auxin transport delaying its GA-induced degradation. Involved in the regulation of seed dormancy and germination, including glucose-induced delay of seed germination (PubMed:24989044).<ref>PMID:11606551</ref> <ref>PMID:11606552</ref> <ref>PMID:12610625</ref> <ref>PMID:14615596</ref> <ref>PMID:14973286</ref> <ref>PMID:15128937</ref> <ref>PMID:16034591</ref> <ref>PMID:17933900</ref> <ref>PMID:20093430</ref> <ref>PMID:24989044</ref> <ref>PMID:9490740</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Islam S]]
[[Category: Kim DY]]
[[Category: Kwon E]]
[[Category: Park K]]