View source for 9ly6


==antibody 20G5 (Fab')2 in complex with human B7-H3==
<StructureSection load='9ly6' size='340' side='right'caption='[[9ly6]], [[Resolution|resolution]] 3.67&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ly6]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9LY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9LY6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.67&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ly6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ly6 OCA], [https://pdbe.org/9ly6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ly6 RCSB], [https://www.ebi.ac.uk/pdbsum/9ly6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ly6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CD276_HUMAN CD276_HUMAN] May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.<ref>PMID:11224528</ref> <ref>PMID:12906861</ref> <ref>PMID:14764704</ref> <ref>PMID:15314238</ref> <ref>PMID:15682454</ref> <ref>PMID:15961727</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: He K]]
[[Category: Li B]]
[[Category: Zhou S]]