View source for 9lzl


==Flat-contact of Flock House Virus early disassembly intermediate==
<StructureSection load='9lzl' size='340' side='right'caption='[[9lzl]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9lzl]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Flock_House_virus Flock House virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9LZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9LZL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9lzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9lzl OCA], [https://pdbe.org/9lzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9lzl RCSB], [https://www.ebi.ac.uk/pdbsum/9lzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9lzl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAPSD_FHV CAPSD_FHV] Capsid protein alpha self-assembles to form an icosahedral procapsid with a T=3 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins trimers. In addition, 240 calcium ions are incorporated per capsid during assembly. The capsid encapsulates the two genomic RNAs. Capsid maturation occurs via autoproteolytic cleavage of capsid protein alpha generating capsid protein beta and the membrane-active peptide gamma.  Peptide gamma: membrane-permeabilizing peptide produced by virus maturation, thereby creating the infectious virion. After endocytosis into the host cell, peptide gamma is probably exposed in endosomes, where it permeabilizes the endosomal membrane, facilitating translocation of viral capsid or RNA into the cytoplasm (Probable).
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</StructureSection>
[[Category: Flock House virus]]
[[Category: Large Structures]]
[[Category: Banerjee M]]
[[Category: Borkotoky S]]
[[Category: Kumar D]]
[[Category: Lokshman MK]]