View source for 9m5b


==A Human Fc Receptor Ectodomain in Complex With a Fab==
<StructureSection load='9m5b' size='340' side='right'caption='[[9m5b]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9m5b]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9M5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9M5B FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.66&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9m5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9m5b OCA], [https://pdbe.org/9m5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9m5b RCSB], [https://www.ebi.ac.uk/pdbsum/9m5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9m5b ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/FCG2B_HUMAN FCG2B_HUMAN] Note=A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression.  Defects in FCGR2B are a cause of susceptibility to systemic lupus erythematosus (SLE) [MIM:[https://omim.org/entry/152700 152700]. A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.<ref>PMID:12115230</ref> <ref>PMID:20385827</ref> 
== Function ==
[https://www.uniprot.org/uniprot/FCG2B_HUMAN FCG2B_HUMAN] Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Duan Y]]
[[Category: Wang H]]
[[Category: Yang H]]
[[Category: Zhang H]]
[[Category: Zhao Z]]