View source for 9m87


==Mo1033, Conopressin from Conus monile==
<StructureSection load='9m87' size='340' side='right'caption='[[9m87]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9m87]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_monile Conus monile]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9M87 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9M87 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR,  models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9m87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9m87 OCA], [https://pdbe.org/9m87 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9m87 RCSB], [https://www.ebi.ac.uk/pdbsum/9m87 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9m87 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Conopressins are single disulfide conopeptides with a close sequence similarity to vasopressin and oxytocin, exhibiting grooming and scratching effects in rodents. Here, we have investigated the impact of stereochemistry on the conserved arginine residue at position 4 and the truncation (Tr-Mo976 and Tr-Mo977) on the structure and activity of conopressins. 3D structures determined by solution NMR revealed distinct structural features for Mo1033 and (D)R4-Mo1033. Molecular dynamics studies of the conopressins with oxytocin and V2 receptor complexes revealed that both Tr-Mo976 and Tr-Mo977 showed robust interactions with the OT receptor and reduced interactions with the V2 receptor. In addition, conopressins exhibited anti-inflammatory and antioxidant potential in LPS-stimulated macrophages. Behavioural studies in mice demonstrated high grooming and scratching behaviour for Tr-Mo976 and reduced locomotory activity with Tr-Mo977. To this end, results suggest that both the truncation of the tail region and the nature of residue 8 play an essential role in altering the activity of conopressins.

Structure and activity of conopressins: insights into in silico oxytocin/V2 receptor interactions, anti-inflammatory potential, and behavioural studies.,Dhurjad P, Bazaz MR, Pati S, Dandekar MP, Godugu C, Sonti R RSC Med Chem. 2025 Jul 4. doi: 10.1039/d5md00288e. PMID:40726970<ref>PMID:40726970</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 9m87" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Conus monile]]
[[Category: Large Structures]]
[[Category: Dhurjad P]]
[[Category: Sonti R]]