View source for 9ma7


==Cryo-EM structure of EBV gp350 D123 in complex with neutralizing antibody 1A12 and 1H5 and non-neutralizing antibody 2E9==
<StructureSection load='9ma7' size='340' side='right'caption='[[9ma7]], [[Resolution|resolution]] 3.14&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ma7]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_4 Human gammaherpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MA7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MA7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.14&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ma7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ma7 OCA], [https://pdbe.org/9ma7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ma7 RCSB], [https://www.ebi.ac.uk/pdbsum/9ma7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ma7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GP350_EBVB9 GP350_EBVB9] Initiates virion attachment to host B-lymphocyte cell, leading to virus entry. Acts by binding to host CR2 at the surface of B-lymphocytes, facilitating the binding of viral glycoprotein gp42 to HLA class II molecules. Attachment triggers virion-host membrane fusion and invasion of the host cell.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Human gammaherpesvirus 4]]
[[Category: Large Structures]]
[[Category: Ma HY]]
[[Category: Sun C]]