View source for 9mbz


==Cryo-EM structure of human FcRL4 bound to IgA-Fc/J==
<StructureSection load='9mbz' size='340' side='right'caption='[[9mbz]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9mbz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MBZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MBZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mbz OCA], [https://pdbe.org/9mbz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mbz RCSB], [https://www.ebi.ac.uk/pdbsum/9mbz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mbz ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/FCRL4_HUMAN FCRL4_HUMAN] A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2).<ref>PMID:12619161</ref>   A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.<ref>PMID:11290337</ref> [https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
== Function ==
[https://www.uniprot.org/uniprot/FCRL4_HUMAN FCRL4_HUMAN] May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.<ref>PMID:14597715</ref> [https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Su C]]
[[Category: Wang YX]]
[[Category: Xiao JY]]