View source for 9mhh


==PI3KC3-C1 in complex with RAB1A. VPS34 kinase domain active conformation==
<StructureSection load='9mhh' size='340' side='right'caption='[[9mhh]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9mhh]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MHH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MHH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mhh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mhh OCA], [https://pdbe.org/9mhh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mhh RCSB], [https://www.ebi.ac.uk/pdbsum/9mhh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mhh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PI3R4_HUMAN PI3R4_HUMAN] Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123).<ref>PMID:20643123</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chen M]]
[[Category: Cook ASI]]
[[Category: Hurley JH]]