View source for 9mjo


==Cryo-EM structure of human NBCn2 bound to Carbonate==
<StructureSection load='9mjo' size='340' side='right'caption='[[9mjo]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9mjo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MJO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mjo OCA], [https://pdbe.org/9mjo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mjo RCSB], [https://www.ebi.ac.uk/pdbsum/9mjo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mjo ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/S4A10_HUMAN S4A10_HUMAN] Neurodevelopmental disorder-slit-like lateral ventricles-intellectual disability syndrome. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/S4A10_HUMAN S4A10_HUMAN] Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (PubMed:18319254). Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (By similarity). Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (PubMed:18319254). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similarity). Acting on presynaptic intracellular pH, it promotes GABA release, reduces the excitability of CA1 pyramidal neurons, and modulates short-term synaptic plasticity (By similarity). Required in retinal cells to maintain normal pH which is necessary for normal vision (By similarity). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (By similarity).[UniProtKB:Q5DTL9][UniProtKB:Q80ZA5]<ref>PMID:18319254</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Capper MJ]]
[[Category: Wacker D]]
[[Category: Warren AL]]
[[Category: Yang S]]
[[Category: Zilberg G]]