View source for 9mlk


==Post-fusion HERV-K Envelope Protein in complex with Kenv-4 Fab==
<StructureSection load='9mlk' size='340' side='right'caption='[[9mlk]], [[Resolution|resolution]] 2.84&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9mlk]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MLK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MLK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.84&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mlk OCA], [https://pdbe.org/9mlk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mlk RCSB], [https://www.ebi.ac.uk/pdbsum/9mlk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mlk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ENK6_HUMAN ENK6_HUMAN] Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.<ref>PMID:14557543</ref>   SU mediates receptor recognition.  TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Hastie K]]
[[Category: Saphire EO]]
[[Category: Shek J]]
[[Category: Sun C]]