View source for 9mm8


==[T:Ag+/Hg2+:T--(pH8-pH9.5; 16s)] Metal-mediated DNA base pair in tensegrity triangle grown at pH 8 and soaked in pH 9.5 for 16s==
<StructureSection load='9mm8' size='340' side='right'caption='[[9mm8]], [[Resolution|resolution]] 4.61&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9mm8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MM8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.61&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mm8 OCA], [https://pdbe.org/9mm8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mm8 RCSB], [https://www.ebi.ac.uk/pdbsum/9mm8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mm8 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The rational design of molecular electronics remains a grand challenge of materials science. DNA nanotechnology has offered unmatched control over molecular geometry, but direct electronic functionalization is a challenge. Here a generalized method is presented for tuning the local band structure of DNA using transmetalation in metal-mediated base pairs (mmDNA). A method is developed for time-resolved X-ray diffraction using self-assembling DNA crystals to establish the exchange of Ag(+) and Hg(2+) in T:T base pairs driven by pH exchange. Transmetalation is tracked over six reaction phases as crystal pH is changed from pH 8.0 to 11.0, and vice versa. A detailed computational analysis of the electronic configuration and transmission in the ensuing crystal structures is then performed. This findings reveal a high conductance contrast in the lowest unoccupied molecular orbitals (LUMO) as a result of metalation. The ability to exchange single transition metal ions as a result of environmental stimuli heralds a means of modulating the conductance of DNA-based molecular electronics. In this way, both theoretical and experimental basis are established by which mmDNA can be leveraged to build rewritable memory devices and nanoelectronics.

Transmetalation for DNA-Based Molecular Electronics.,De A, Lu B, Ohayon YP, Woloszyn K, Livernois W, Perren L, Yang CF, Mao C, Botana AS, Hihath J, Canary JW, Sha R, Anantram MP, Vecchioni S Small. 2025 Jun;21(25):e2411518. doi: 10.1002/smll.202411518. Epub 2025 May 13. PMID:40364470<ref>PMID:40364470</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 9mm8" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Lu B]]
[[Category: Vecchioni S]]