View source for 9mnw


==Cryo-EM structure of human MPC in complex with GW604714==
<StructureSection load='9mnw' size='340' side='right'caption='[[9mnw]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9mnw]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MNW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MNW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.35&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BM8:(5E)-5-({(5P)-5-[6-(4-acetylpiperazin-1-yl)-3-nitropyridin-2-yl]-2-fluorophenyl}methylidene)-1,3-thiazolidine-2,4-dione'>A1BM8</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mnw OCA], [https://pdbe.org/9mnw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mnw RCSB], [https://www.ebi.ac.uk/pdbsum/9mnw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mnw ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/MPC1_HUMAN MPC1_HUMAN] Mitochondrial pyruvate carrier deficiency. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/MPC1_HUMAN MPC1_HUMAN] Mediates the uptake of pyruvate into mitochondria.<ref>PMID:22628558</ref> <ref>PMID:26253029</ref> <ref>PMID:27317664</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Synthetic construct]]
[[Category: Feng L]]
[[Category: Zhang J]]