View source for 9mnz


==Cryo-EM structure of human MPC in complex with UK5099 in nanodiscs==
<StructureSection load='9mnz' size='340' side='right'caption='[[9mnz]], [[Resolution|resolution]] 2.73&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9mnz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MNZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MNZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.73&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I2R:(~{E})-2-cyano-3-(1-phenylindol-3-yl)prop-2-enoic+acid'>I2R</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mnz OCA], [https://pdbe.org/9mnz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mnz RCSB], [https://www.ebi.ac.uk/pdbsum/9mnz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mnz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MPC2_HUMAN MPC2_HUMAN] Mediates the uptake of pyruvate into mitochondria.<ref>PMID:22628558</ref> <ref>PMID:26253029</ref> <ref>PMID:27317664</ref> <ref>PMID:29472561</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Synthetic construct]]
[[Category: Feng L]]
[[Category: He Z]]
[[Category: Zhang J]]