View source for 9moa


==Structure of native murine cardiac thin filament variant I79N in troponin T at pCa=5.8 in Ca2+-free tilted state (lower strand)==
<StructureSection load='9moa' size='340' side='right'caption='[[9moa]], [[Resolution|resolution]] 5.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9moa]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MOA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MOA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9moa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9moa OCA], [https://pdbe.org/9moa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9moa RCSB], [https://www.ebi.ac.uk/pdbsum/9moa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9moa ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TPM1_MOUSE TPM1_MOUSE] Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.[UniProtKB:P09493]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Galkin VE]]
[[Category: Risi CM]]