View source for 9msx


==Candida albicans Hsp90 nucleotide binding domain in complex with TAS116==
<StructureSection load='9msx' size='340' side='right'caption='[[9msx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9msx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MSX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MSX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BPC:3-ethyl-4-[4-[4-(1-methylpyrazol-4-yl)imidazol-1-yl]-3-propan-2-yl-pyrazolo[3,4-b]pyridin-1-yl]benzamide'>A1BPC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9msx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9msx OCA], [https://pdbe.org/9msx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9msx RCSB], [https://www.ebi.ac.uk/pdbsum/9msx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9msx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HSP90_CANAL HSP90_CANAL] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity).
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</StructureSection>
[[Category: Candida albicans]]
[[Category: Large Structures]]
[[Category: Kowalewski ME]]
[[Category: Redinbo MR]]