View source for 9mt3


==Candida albicans Hsp90 nucleotide binding domain in complex with XL888==
<StructureSection load='9mt3' size='340' side='right'caption='[[9mt3]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9mt3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MT3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.02&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=99B:5-[(2R)-BUTAN-2-YLAMINO]-N-{(3-ENDO)-8-[5-(CYCLOPROPYLCARBONYL)PYRIDIN-2-YL]-8-AZABICYCLO[3.2.1]OCT-3-YL}-2-METHYLBENZENE-1,4-DICARBOXAMIDE'>99B</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mt3 OCA], [https://pdbe.org/9mt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mt3 RCSB], [https://www.ebi.ac.uk/pdbsum/9mt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mt3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HSP90_CANAL HSP90_CANAL] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity).
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</StructureSection>
[[Category: Candida albicans]]
[[Category: Large Structures]]
[[Category: Kowalewski ME]]
[[Category: Redinbo MR]]