View source for 9mu6


==Structure of native Drosophila melanogaster DLST==
<StructureSection load='9mu6' size='340' side='right'caption='[[9mu6]], [[Resolution|resolution]] 3.66&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9mu6]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MU6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MU6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.66&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mu6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mu6 OCA], [https://pdbe.org/9mu6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mu6 RCSB], [https://www.ebi.ac.uk/pdbsum/9mu6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mu6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9VGQ1_DROME Q9VGQ1_DROME] Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.[ARBA:ARBA00046046]
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Anand G]]
[[Category: Armache J-P]]
[[Category: Babitzke P]]
[[Category: Dollinger R]]
[[Category: Gilmour DS]]
[[Category: Murakami K]]
[[Category: Schultz J]]
[[Category: Venette-Smith NL]]
[[Category: Venkatakrishnan V]]
[[Category: Vishwakarma RK]]