View source for 9mvc


==DENV3 mature structure at 4 degree Celsius==
<StructureSection load='9mvc' size='340' side='right'caption='[[9mvc]], [[Resolution|resolution]] 3.59&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9mvc]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MVC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MVC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.59&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mvc OCA], [https://pdbe.org/9mvc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mvc RCSB], [https://www.ebi.ac.uk/pdbsum/9mvc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mvc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q6DRA0_DENV3 Q6DRA0_DENV3] Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.[ARBA:ARBA00024317]  Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[ARBA:ARBA00003504]  Regulates the ATPase activity of the NS3 helicase activity. NS4A allows NS3 helicase to conserve energy during unwinding. Plays a role in the inhibition of the host innate immune response. Interacts with host MAVS and thereby prevents the interaction between RIGI and MAVS. In turn, IFN-beta production is impaired. Interacts with host AUP1 which mediates induction of lipophagy in host cells and facilitates production of virus progeny particles.[ARBA:ARBA00045521]  Required cofactor for the serine protease function of NS3. May have membrane-destabilizing activity and form viroporins.[ARBA:ARBA00035601]
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</StructureSection>
[[Category: Dengue virus 3]]
[[Category: Large Structures]]
[[Category: Are VN]]
[[Category: Fokine A]]
[[Category: Klose T]]
[[Category: Kuhn RJ]]