View source for 9mvu


==C6 Herpes Virus Simplex Neutralizing Nanobody Bound to HSV Glycoprotein gB==
<StructureSection load='9mvu' size='340' side='right'caption='[[9mvu]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9mvu]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MVU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MVU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mvu OCA], [https://pdbe.org/9mvu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mvu RCSB], [https://www.ebi.ac.uk/pdbsum/9mvu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mvu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GB_HHV11 GB_HHV11] Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress (By similarity). Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation).[HAMAP-Rule:MF_04032]<ref>PMID:15596825</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Human alphaherpesvirus 1 strain 17]]
[[Category: Large Structures]]
[[Category: Abernathy E]]
[[Category: Hung M]]
[[Category: Lee CV]]
[[Category: Viadiu H]]
[[Category: Xing W]]
[[Category: Yu X]]
[[Category: Yu Y]]