View source for 9mzg


==Cryo-EM structure of GCGR-Gs complex with glucagon==
<StructureSection load='9mzg' size='340' side='right'caption='[[9mzg]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9mzg]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MZG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MZG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mzg OCA], [https://pdbe.org/9mzg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mzg RCSB], [https://www.ebi.ac.uk/pdbsum/9mzg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mzg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GLR_HUMAN GLR_HUMAN] This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Belousoff MJ]]
[[Category: Jiang Y]]
[[Category: Sexton PM]]
[[Category: Wootten D]]
[[Category: Zhang X]]