View source for 9n3s


==Crystal structure of the fungal mannosyltransferase Och1 reveals active site primed for N-glycan binding==
<StructureSection load='9n3s' size='340' side='right'caption='[[9n3s]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9n3s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9N3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9N3S FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9n3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9n3s OCA], [https://pdbe.org/9n3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9n3s RCSB], [https://www.ebi.ac.uk/pdbsum/9n3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9n3s ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/OCH1_YEAST OCH1_YEAST] Mannosyltransferase involved in outer chain elongation of asparagine-linked oligosaccharides of the type Man(9)GlcNAc(2). Adds the first alpha-1,6-mannose to the Man(8)GlcNAc(2) and Man(9)GlcNAc(2), but not Man(5)GlcNAc(2), endoplasmic reticulum intermediates. Represents the first enzymatic event required for synthesis of outer chain mannose linkages on yeast secretory proteins. Also has the potential to transfer a second alpha-1,6-mannose to the Man(8)GlcNAc(2) core oligosaccharide.<ref>PMID:1523886</ref> <ref>PMID:1628616</ref> <ref>PMID:17042779</ref> <ref>PMID:21979948</ref> <ref>PMID:7649302</ref> <ref>PMID:8253757</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Berghuis AM]]
[[Category: Kelly ETR]]
[[Category: Rodionov D]]