View source for 9nac


==Structure of HPK1 with C4 bound at its active site==
<StructureSection load='9nac' size='340' side='right'caption='[[9nac]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9nac]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NAC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NAC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BWM:3,3-dimethyl-5-[[5-[3-(oxan-4-yl)-1,2,4-oxadiazol-5-yl]-4-[[(1~{S})-2-oxidanyl-1-phenyl-ethyl]amino]pyrimidin-2-yl]amino]-2-benzofuran-1-one'>A1BWM</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nac OCA], [https://pdbe.org/9nac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nac RCSB], [https://www.ebi.ac.uk/pdbsum/9nac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nac ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/M4K1_HUMAN M4K1_HUMAN] Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.<ref>PMID:24362026</ref> <ref>PMID:8824585</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dou Y]]
[[Category: Kiefer JR]]
[[Category: Walters BT]]
[[Category: Wang W]]
[[Category: Wu P]]