View source for 9nda


==The rigid portion of Cryo-EM structure of Herpesvirus Helicase-Primase complex with amenamevir==
<StructureSection load='9nda' size='340' side='right'caption='[[9nda]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9nda]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Herpesviridae Herpesviridae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NDA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nda OCA], [https://pdbe.org/9nda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nda RCSB], [https://www.ebi.ac.uk/pdbsum/9nda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nda ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PRIM_HHV11 PRIM_HHV11] Essential component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.[HAMAP-Rule:MF_04011]<ref>PMID:7775476</ref> <ref>PMID:8189507</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Herpesviridae]]
[[Category: Large Structures]]
[[Category: Yao Q]]
[[Category: Yu X]]