View source for 9ndt


==The flexible portion of Cryo-EM structure of Herpesvirus Helicase-Primase complex prepared with forked DNA and ATP-gamma-S==
<StructureSection load='9ndt' size='340' side='right'caption='[[9ndt]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ndt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Herpesviridae Herpesviridae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NDT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ndt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ndt OCA], [https://pdbe.org/9ndt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ndt RCSB], [https://www.ebi.ac.uk/pdbsum/9ndt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ndt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PRIM_HHV11 PRIM_HHV11] Essential component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.[HAMAP-Rule:MF_04011]<ref>PMID:7775476</ref> <ref>PMID:8189507</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Herpesviridae]]
[[Category: Large Structures]]
[[Category: Yao Q]]
[[Category: Yu X]]