View source for 9ndz


==The rigid portion of Cryo-EM structure of Herpesvirus Helicase-Primase complex prepared with forked DNA, ATP-gamma-S and Pritelivir==
<StructureSection load='9ndz' size='340' side='right'caption='[[9ndz]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ndz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Herpesviridae Herpesviridae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NDZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NDZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ndz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ndz OCA], [https://pdbe.org/9ndz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ndz RCSB], [https://www.ebi.ac.uk/pdbsum/9ndz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ndz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PRIM_HHV11 PRIM_HHV11] Essential component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.[HAMAP-Rule:MF_04011]<ref>PMID:7775476</ref> <ref>PMID:8189507</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Herpesviridae]]
[[Category: Large Structures]]
[[Category: Yao Q]]
[[Category: Yu X]]