View source for 9nel


==The flexible portion of Cryo-EM structure of Herpesvirus Helicase-Primase complex with amenamevir==
<StructureSection load='9nel' size='340' side='right'caption='[[9nel]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9nel]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Herpesviridae Herpesviridae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NEL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BXD:N-(2,6-dimethylphenyl)-N-{2-[4-(1,2,4-oxadiazol-3-yl)anilino]-2-oxoethyl}-1,1-dioxo-1lambda~6~-thiane-4-carboxamide'>A1BXD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nel OCA], [https://pdbe.org/9nel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nel RCSB], [https://www.ebi.ac.uk/pdbsum/9nel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nel ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PRIM_HHV11 PRIM_HHV11] Essential component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.[HAMAP-Rule:MF_04011]<ref>PMID:7775476</ref> <ref>PMID:8189507</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Herpesviridae]]
[[Category: Large Structures]]
[[Category: Yao Q]]
[[Category: Yu X]]