View source for 9ngx


==Structure of the 5'SL-bound La Domain of the Human La-related Protein 6==
<StructureSection load='9ngx' size='340' side='right'caption='[[9ngx]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ngx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NGX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NGX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ngx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ngx OCA], [https://pdbe.org/9ngx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ngx RCSB], [https://www.ebi.ac.uk/pdbsum/9ngx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ngx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LARP6_HUMAN LARP6_HUMAN] Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9.<ref>PMID:20603131</ref> <ref>PMID:21746880</ref> <ref>PMID:22190748</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Gordon BH]]
[[Category: Silvers R]]