View source for 9njy


==Terminal two domains of ClfA002 with bound Fab of AZD7745==
<StructureSection load='9njy' size='340' side='right'caption='[[9njy]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9njy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mammalia Mammalia] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NJY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9njy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9njy OCA], [https://pdbe.org/9njy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9njy RCSB], [https://www.ebi.ac.uk/pdbsum/9njy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9njy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CLFA_STAAN CLFA_STAAN] Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps, which diminish the ability of group IIA phospholipase A2 to cause bacterial phospholipid hydrolysis and killing. Significantly decreases macrophage phagocytosis possibly thanks to the clumps, clumped bacteria being too large to be phagocytosed. Dominant factor responsible for human platelet aggregation, which may be an important mechanism for initiating infective endocarditis (By similarity).
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mammalia]]
[[Category: Staphylococcus aureus]]
[[Category: Oganesyan VY]]