View source for 9nn3


==BET BRD2-BD1 in complex with peptide 6.2==
<StructureSection load='9nn3' size='340' side='right'caption='[[9nn3]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9nn3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NN3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NN3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nn3 OCA], [https://pdbe.org/9nn3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nn3 RCSB], [https://www.ebi.ac.uk/pdbsum/9nn3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nn3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The large size of macrocyclic peptides discovered by mRNA display can hinder therapeutic development. Using size-restricted RaPID libraries and analysis of 40 published datasets, we show that potent binders are more reliably identified from libraries with at least nine randomised residues, providing guidance for mRNA display screen design.

The effect of peptide size on target affinity in mRNA display-derived macrocyclic peptides.,Jing X, Suh J, Maxwell J, Patel K, Norman A, Reid XJ, Deshpande C, Low JKK, Payne RJ, Passioura T, Mackay JP Chem Commun (Camb). 2026 Jan 30. doi: 10.1039/d5cc06167a. PMID:41614404<ref>PMID:41614404</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 9nn3" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Deshpande C]]
[[Category: Jing X]]
[[Category: Mackay JP]]
[[Category: Patel K]]