View source for 9nnb


==Cryo-EM structure of the Retron Ec78 complex, PtuA:PtuB:RT (4:2:1)==
<StructureSection load='9nnb' size='340' side='right'caption='[[9nnb]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9nnb]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NNB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nnb OCA], [https://pdbe.org/9nnb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nnb RCSB], [https://www.ebi.ac.uk/pdbsum/9nnb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nnb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ATP78_ECOLX ATP78_ECOLX] Probable ATPase component of antiviral defense system retron Ec78, composed of a non-coding RNA (ncRNA), a reverse transcriptase (RT), this protein and a putative HNH endonuclease. Expression of retron Ec78 confers protection against bacteriophage T5. At multiplicity of infection (MOI) of 0.02 cultures slow growth when infected with T5 but do not collapse, at MOI 2 cultures enter growth stasis.<ref>PMID:33157039</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Li H]]
[[Category: Wang B]]