View source for 9nnh


==Cryo-EM structure of the Retron Ec78 complex, PtuA:PtuB:RT (4:2:2)==
<StructureSection load='9nnh' size='340' side='right'caption='[[9nnh]], [[Resolution|resolution]] 2.69&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9nnh]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NNH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NNH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.69&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nnh OCA], [https://pdbe.org/9nnh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nnh RCSB], [https://www.ebi.ac.uk/pdbsum/9nnh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nnh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ATP78_ECOLX ATP78_ECOLX] Probable ATPase component of antiviral defense system retron Ec78, composed of a non-coding RNA (ncRNA), a reverse transcriptase (RT), this protein and a putative HNH endonuclease. Expression of retron Ec78 confers protection against bacteriophage T5. At multiplicity of infection (MOI) of 0.02 cultures slow growth when infected with T5 but do not collapse, at MOI 2 cultures enter growth stasis.<ref>PMID:33157039</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Li H]]
[[Category: Wang B]]