View source for 9noy


==Human TAS1R2 transmembrane domains from the TAS1R2-TM-G protein complex==
<StructureSection load='9noy' size='340' side='right'caption='[[9noy]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9noy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NOY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NOY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9noy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9noy OCA], [https://pdbe.org/9noy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9noy RCSB], [https://www.ebi.ac.uk/pdbsum/9noy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9noy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TS1R2_HUMAN TS1R2_HUMAN] Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
In humans, the detection and ultimately the perception of sweetness begin in the oral cavity, where taste receptor cells (TRCs) dedicated to sweet-sensing interact with sugars, artificial sweeteners, and other sweet-tasting chemicals. Human sweet TRCs express on their cell surface a sweet receptor that initiates the cascade of signaling events responsible for our strong attraction to sweet stimuli. Here, we describe the cryo-electron microscopy (cryo-EM) structure of the human sweet receptor bound to two of the most widely used artificial sweeteners-sucralose and aspartame. Our results reveal the structural basis for sweet detection, provide insights into how a single receptor mediates all our responses to such a wide range of sweet-tasting compounds, and open up unique possibilities for designing a generation of taste modulators informed by the structure of the human receptor.

The structure of human sweetness.,Juen Z, Lu Z, Yu R, Chang AN, Wang B, Fitzpatrick AWP, Zuker CS Cell. 2025 May 2:S0092-8674(25)00456-8. doi: 10.1016/j.cell.2025.04.021. PMID:40339580<ref>PMID:40339580</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 9noy" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chang AN]]
[[Category: Fitzpatrick AWP]]
[[Category: Juen Z]]
[[Category: Lu Z]]
[[Category: Wang B]]
[[Category: Yu R]]
[[Category: Zuker CS]]