View source for 9nrc


==TMPRSS6 in complex with REGN7999 Fab and REGN8023 Fab==
<StructureSection load='9nrc' size='340' side='right'caption='[[9nrc]], [[Resolution|resolution]] 3.29&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9nrc]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NRC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NRC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.29&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nrc OCA], [https://pdbe.org/9nrc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nrc RCSB], [https://www.ebi.ac.uk/pdbsum/9nrc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nrc ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/TMPS6_HUMAN TMPS6_HUMAN] IRIDA syndrome. The disease is caused by variants affecting the gene represented in this entry. Mutations leading to abrogation of TMPRSS6 activity are associated with IRIDA due to elevated levels of hepcidin, a negative regulator of plasma iron pool (PubMed:20232450).<ref>PMID:20232450</ref> 
== Function ==
[https://www.uniprot.org/uniprot/TMPS6_HUMAN TMPS6_HUMAN] Membrane-bound serine protease (PubMed:18976966, PubMed:20518742, PubMed:25156943, PubMed:25588876). Through the cleavage of cell surface hemojuvelin (HJV), a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis (PubMed:18408718, PubMed:18976966, PubMed:25156943).<ref>PMID:18408718</ref> <ref>PMID:18976966</ref> <ref>PMID:20518742</ref> <ref>PMID:25156943</ref> <ref>PMID:25588876</ref> <ref>PMID:25156943</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Franklin MC]]
[[Category: Saotome K]]