View source for 9ntc


==Structure of Synaptic Vesicle Protein 2A Bound to Brivaracetam and UCB1244283==
<StructureSection load='9ntc' size='340' side='right'caption='[[9ntc]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ntc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NTC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.05&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1B1I:(3S)-4-(3,5-dimethylphenyl)-N-(2-methoxyphenyl)-3-methylbutanamide'>A1B1I</scene>, <scene name='pdbligand=A1B1J:(3R)-4-(3,5-dimethylphenyl)-N-(2-methoxyphenyl)-3-methylbutanamide'>A1B1J</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=VLX:(2~{S})-2-[(4~{R})-2-oxidanylidene-4-propyl-pyrrolidin-1-yl]butanamide'>VLX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ntc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ntc OCA], [https://pdbe.org/9ntc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ntc RCSB], [https://www.ebi.ac.uk/pdbsum/9ntc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ntc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SV2A_HUMAN SV2A_HUMAN] Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Coleman JA]]
[[Category: Horanyi PS]]
[[Category: Ledecq M]]
[[Category: Martin MF]]
[[Category: Mittal A]]