View source for 9nyy


==Nucleic acid bound human SLFN14, State 1==
<StructureSection load='9nyy' size='340' side='right'caption='[[9nyy]], [[Resolution|resolution]] 2.73&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9nyy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NYY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.73&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nyy OCA], [https://pdbe.org/9nyy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nyy RCSB], [https://www.ebi.ac.uk/pdbsum/9nyy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nyy ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SLN14_HUMAN SLN14_HUMAN] Autosomal dominant thrombocytopenia with platelet secretion defect. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/SLN14_HUMAN SLN14_HUMAN] Shows no ribosome-associated and endoribonuclease activities.<ref>PMID:25996083</ref>   Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs (PubMed:25996083). May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs (Probable). Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner (By similarity). Involved in correct maturation of megakaryocytes and especially important for proplatelet extension.[UniProtKB:G1SRW8]<ref>PMID:25996083</ref> <ref>PMID:26769223</ref> <ref>PMID:25996083</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Maheshwari S]]
[[Category: Martinez-Claros AO]]
[[Category: Pillon MC]]
[[Category: Schneiderman H]]
[[Category: Van Riper J]]
[[Category: Wang L]]