View source for 9o93


==Cryo-EM structure of KCa2.2_II/calmodulin channel in complex with rimtuzalcap==
<StructureSection load='9o93' size='340' side='right'caption='[[9o93]], [[Resolution|resolution]] 2.96&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9o93]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9O93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9O93 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.96&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1B92:~{N}-[4,4-bis(fluoranyl)cyclohexyl]-2-(3-methylpyrazol-1-yl)-6-morpholin-4-yl-pyrimidin-4-amine'>A1B92</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9o93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9o93 OCA], [https://pdbe.org/9o93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9o93 RCSB], [https://www.ebi.ac.uk/pdbsum/9o93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9o93 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KCNN2_RAT KCNN2_RAT] Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Nam YW]]
[[Category: Zhang M]]