View source for 9omf


==Cryo-EM structure of neddylated PCMTD1-ELOBC-CUL5-RBX2 (N8-CRL5-PCMTD1)==
<StructureSection load='9omf' size='340' side='right'caption='[[9omf]], [[Resolution|resolution]] 9.72&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9omf]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9OMF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9OMF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 9.72&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9omf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9omf OCA], [https://pdbe.org/9omf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9omf RCSB], [https://www.ebi.ac.uk/pdbsum/9omf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9omf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PCMD1_HUMAN PCMD1_HUMAN] Substrate recognition component of an ECS (Elongin BC-CUL5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:35486881). Specifically binds to the methyltransferase cofactor S-adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but does not display methyltransferase activity (PubMed:35486881). May provide an alternate maintenance pathway for modified proteins by acting as a damage-specific E3 ubiquitin ligase adaptor protein (PubMed:35486881).<ref>PMID:35486881</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Clarke SG]]
[[Category: Flowers C]]
[[Category: Loo JA]]
[[Category: Oroudjeva E]]
[[Category: Pandey V]]
[[Category: Pang EZ]]
[[Category: Rodriguez JA]]
[[Category: Sawaya MR]]
[[Category: Winters JB]]
[[Category: Wohlschlegel W]]
[[Category: Zhao B]]