View source for 9omr


==The desensitized state structure of human P2X2 receptor channel in lipid nanodiscs with free ATP and sodium==
<StructureSection load='9omr' size='340' side='right'caption='[[9omr]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9omr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9OMR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9OMR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.68&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9omr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9omr OCA], [https://pdbe.org/9omr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9omr RCSB], [https://www.ebi.ac.uk/pdbsum/9omr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9omr ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/P2RX2_HUMAN P2RX2_HUMAN] Rare autosomal dominant non-syndromic sensorineural deafness type DFNA. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/P2RX2_HUMAN P2RX2_HUMAN] ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:10570044, PubMed:31636190). Activation by extracellular ATP induces a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis (By similarity). In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling (PubMed:23345450). Mediates synaptic transmission between neurons and from neurons to smooth muscle (By similarity).[UniProtKB:Q8K3P1]<ref>PMID:10570044</ref> <ref>PMID:23345450</ref> <ref>PMID:31636190</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dhingra S]]
[[Category: Swartz KJ]]