View source for 9omz


==Cryo-EM structure of a pentameric RAD51-XRCC3-RAD51C-RAD51D-XRCC2 (51-X3CDX2) complex.==
<StructureSection load='9omz' size='340' side='right'caption='[[9omz]], [[Resolution|resolution]] 3.51&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9omz]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9OMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9OMZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.51&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9omz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9omz OCA], [https://pdbe.org/9omz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9omz RCSB], [https://www.ebi.ac.uk/pdbsum/9omz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9omz ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/XRCC3_HUMAN XRCC3_HUMAN] Disease susceptibility is associated with variants affecting the gene represented in this entry.  Disease susceptibility may be associated with variants affecting the gene represented in this entry. Variant p.Thr341Met has been reported to be associated with an increased risk for CMM6 (PubMed:11059748). Further studies have shown that this variant is functional in homology-directed DNA repair, and the association of XRCC3 with CMM6 has not been confirmed (PubMed:12037675, PubMed:12376526, PubMed:26137085, PubMed:26922354).<ref>PMID:11059748</ref> <ref>PMID:12037675</ref> <ref>PMID:12376526</ref> <ref>PMID:26137085</ref> <ref>PMID:26922354</ref> 
== Function ==
[https://www.uniprot.org/uniprot/XRCC3_HUMAN XRCC3_HUMAN] Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.<ref>PMID:14716019</ref> <ref>PMID:20413593</ref> <ref>PMID:23108668</ref> <ref>PMID:23149936</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Jia L]]
[[Category: Kwon Y]]
[[Category: Olsen SK]]
[[Category: Rawal Y]]
[[Category: Ruben EA]]
[[Category: Sung P]]
[[Category: Wasmuth EV]]