View source for 9ovo


==Cryo-EM structure of HCoV-OC43-C2 Spike glycoprotein in complex with 9O-acetyl GD3 sialoglycan (Local refined D1 domain)==
<StructureSection load='9ovo' size='340' side='right'caption='[[9ovo]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ovo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_coronavirus_OC43 Human coronavirus OC43]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9OVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9OVO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1AR1:(2~{R},4~{S},5~{R},6~{R})-5-acetamido-6-[(1~{S},2~{R})-2-[(2~{S},4~{S},5~{R},6~{R})-5-acetamido-6-[(1~{R},2~{R})-3-acetyloxy-1,2-bis(oxidanyl)propyl]-2-carboxy-4-oxidanyl-oxan-2-yl]oxy-1,3-bis(oxidanyl)propyl]-2,4-bis(oxidanyl)oxane-2-carboxylic+acid'>A1AR1</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ovo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ovo OCA], [https://pdbe.org/9ovo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ovo RCSB], [https://www.ebi.ac.uk/pdbsum/9ovo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ovo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A1V0BZ81_CVHOC A0A1V0BZ81_CVHOC] Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099]  Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]  Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099]
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</StructureSection>
[[Category: Human coronavirus OC43]]
[[Category: Large Structures]]
[[Category: Jin M]]
[[Category: Rini JM]]