View source for 9ovr


==CryoEM structural insight into the breast cancer pH regulator NBCn1==
<StructureSection load='9ovr' size='340' side='right'caption='[[9ovr]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ovr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9OVR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9OVR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ovr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ovr OCA], [https://pdbe.org/9ovr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ovr RCSB], [https://www.ebi.ac.uk/pdbsum/9ovr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ovr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/S4A7_HUMAN S4A7_HUMAN] Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry (PubMed:10347222, PubMed:12403779, PubMed:14578046, PubMed:14736710). Mediates the sodium-dependent bicarbonate transport important for pH recovery after acid load as well as for regulation of steady-state pH in the duodenum and vascular smooth muscle cells (By similarity). Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis (PubMed:29779931). Provides cellular bicarbonate for de novo purine and pyrimidine synthesis and is a key mediator of de novo nucleotide synthesis downstream of mTORC1 signaling in proliferating cells (PubMed:35772404).[UniProtKB:Q8BTY2]<ref>PMID:10347222</ref> <ref>PMID:12403779</ref> <ref>PMID:14578046</ref> <ref>PMID:14736710</ref> <ref>PMID:29779931</ref> <ref>PMID:35772404</ref>   Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis.<ref>PMID:29779931</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Alexander P]]
[[Category: Hong Z]]
[[Category: Hristina RZ]]
[[Category: Ira K]]
[[Category: Kirill T]]
[[Category: Weiguang W]]