View source for 9oyq


==Structure of D10-NT amyloid fibrils==
<StructureSection load='9oyq' size='340' side='right'caption='[[9oyq]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9oyq]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9OYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9OYQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9oyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9oyq OCA], [https://pdbe.org/9oyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9oyq RCSB], [https://www.ebi.ac.uk/pdbsum/9oyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9oyq ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CHC10_HUMAN CHC10_HUMAN] Frontotemporal dementia with motor neuron disease;Autosomal dominant mitochondrial myopathy with exercise intolerance;Amyotrophic lateral sclerosis;Lower motor neuron syndrome with late-adult onset. The disease is caused by variants affecting the gene represented in this entry. The pathological events leading to disease involve fragmentation of the mitochondrial network, mitochondrial ultrastructural abnormalities including loss, disorganization and dilatation of cristae, and mitochondrial dysfunction associated with respiratory chain deficiency (PubMed:24934289).<ref>PMID:24934289</ref>   The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/CHC10_HUMAN CHC10_HUMAN] May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure.<ref>PMID:24934289</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Eliezer D]]
[[Category: Lv G]]